Getting to the crash takes a few weeks of actively using the remote screen a few hours per day without restarting SpaceDesk. The 17TB in my screen cap was about a week after updating to 0.46. Between the timing and the tendency of most computer things aligning with powers of two, I’m guessing the out-of-memory system collapse happens at either 32TB or 64TB on my setup. The system runs out of physical memory tracking virtual memory that gets allocated on every screen update but never actually used.
Technically, the system didn’t quite crash back then. The OS terminated processes left and right to free up memory and put the system in an unusable state where attempting to do anything resulted in out-of-memory errors until enough of whatever was still running got OoM-crashed on shutdown to free up memory for the remainder to shut down normally.